Motion-resolved four dimensional diffusion-weighted echo-planar imaging (4D-DW-EPI) may better characterize the respiratory-induced motion of tumor than 4D-MRI with conventional T1 and T2 image contrasts. However, the existing 4D-DW-EPI technique can only provide limited geometric accuracy and low sampling rate over respiratory cycles. Thus, we proposed an advanced 4D-DW-Propeller-EPI technique with golden angle acquisition for improving the geometric accuracy and data sampling rate. Simulation study and in-vivo study were conducted to evaluate the performance of 4D-DW-Propeller-EPI. Our results demonstrate that 4D-DW-Propeller-EPI showed superior image quality to 4D-DW-EPI and had a potential for the application of MRI-guided abdominal radiotherapy.