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Abstract #0386

An interstitial fluid proxy of altered glymphatics in Alzheimer’s disease: the necessity of three-directional intravoxel incoherent motion

Merel M. van der Thiel1,2, Whitney M. Freeze2,3,4, Joost de Jong1,2, Inez H.G.B. Ramakers2,4, Walter H. Backes1,2,5, and Jacobus F.A. Jansen1,2,6
1Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2School for Mental Health & Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands, 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands, 5School for Cardiovascular Disease, Maastricht University, Maastricht, Netherlands, 6Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

The interstitial fluid fraction assessed with spectral analysis in intravoxel-incoherent motion MRI can be a potential, non-invasive method to identify tissue damage on a microscopic level and to investigate glymphatic alterations within different disease states. The current multi-dimensional approach has a long acquisition time, thereby lowering the feasibility of IVIM as a measurement of ISF in clinical practice. This study simultaneously investigates potential group differences in the ISF-fraction in Alzheimer’s disease, mild cognitive impairment, and controls, and explores the possibility to shorten acquisition time drastically by examining the contribution of individual primary directions.

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