Abstract #0445

Simultaneous optimisation of MP2RAGE UNI and FLAWS brain images at 7T using Extended Phase Graph (EPG) Simulations

Ayse Sila Dokumaci¹, Fraser R. Aitken¹, Jan Sedlacik¹, Philippa Bridgen¹, Raphael Tomi-Tricot^1,2, Tom Wilkinson¹, Ronald Mooiweer¹, Sharon Giles¹, Joseph V. Hajnal¹, Shaihan Malik¹, Jonathan O'Muircheartaigh¹, and David W. Carmichael¹

¹Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, ²MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom

The MP2RAGE sequence is typically used at 7T to produce UNI image with maximised contrast between WM-GM and GM-CSF while mitigating B₁^- field variability. It can also be optimised to obtain Fluid and White Matter Suppression (FLAWS) images but this is typically done separately. Here, the Extended Phase Graph formalism was used to optimise both FLAWS and UNI images at 7T within one acquisition while minimising B₁⁺ sensitivity. Different combinations were tested in healthy subjects with 0.65mm isotropic resolution demonstrating that UNI and FLAWS images could be obtained together while largely maintaining image quality.

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