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Abstract #0464

fMRI deconvolution with synthesis-based Paradigm Free Mapping and analysis-based Total Activation operate identically

Eneko Uruñuela1, Stefano Moia1, and César Caballero-Gaudes1
1Basque Center on Cognition, Brain and Language, Donostia - San Sebastián, Spain

Functional MRI deconvolution algorithms are gaining popularity to study the dynamicss of functional brain activity and connectivity at short timescales. This work sheds light on our understanding of two state-of-the-art approaches based on L1-norm regularized estimators: Paradigm Free Mapping (synthesis model) and Total Activation (analysis model). Through simulations with varying signal-to-noise ratios, and an experimental motor task dataset, we demonstrate that both formulations produce identical estimates of the innovation and activity-inducing signals underlying BOLD events when identical hemodynamic response and regularization parameters are used. These observations open up the possibility for future developments without questioning their core formulation and performance.

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