High-resolution (iso-1mm) 7T ASL scans were performed on the primary motor cortex (M1) to characterize layer-dependent resting CBF, and perfusion activity to sensory input/motor output. Finger tapping (FT)-induced CBF increase shows a clear ‘double-peak’ pattern, consistent with the hypothesis that FT engaged neural activity of somatosensory input in the superficial layers and motor output in the deep layers. Finger brushing (FB)-induced CBF increase was overall smaller, and mainly peaked in superficial layers (somatosensory input and minimal motor output). These results demonstrate the high spatial specificity of 7T ASL, capable of resolving layer-dependent input and output activity in human M1.
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