Abstract #0467

Layer-dependent 7T ASL reveals sensory input and motor output perfusion activity in human primary motor cortex

Xingfeng Shao¹, Fanhua Guo², Qinyang Shou¹, Kai Wang¹, Lirong Yan^1,3, Kay Jann^1,3, Peng Zhang², and Danny JJ Wang^1,3

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ³Department of Neurology, University of Southern California, Los Angeles, CA, United States

High-resolution (iso-1mm) 7T ASL scans were performed on the primary motor cortex (M1) to characterize layer-dependent resting CBF, and perfusion activity to sensory input/motor output. Finger tapping (FT)-induced CBF increase shows a clear ‘double-peak’ pattern, consistent with the hypothesis that FT engaged neural activity of somatosensory input in the superficial layers and motor output in the deep layers. Finger brushing (FB)-induced CBF increase was overall smaller, and mainly peaked in superficial layers (somatosensory input and minimal motor output). These results demonstrate the high spatial specificity of 7T ASL, capable of resolving layer-dependent input and output activity in human M1.

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