The cerebrovascular system is altered in MS. Using breath-hold BOLD-MRI, we tested whether pharmacological modulation of MS inflammation influences alteration in cerebrovascular reactivity (CVR). We found that CVR increased with immunomodulation and this increase was negatively correlated with pre-treatment CVR, suggesting that cerebrovascular alteration reflects disease activity. Moreover, lower CVR in the pre-treatment phase was associated with lower grey matter volume and this correlation was lost with immunomodulation, indicating an involvement of brain vasculature in neurodegeneration. Given the multiparametric characteristic of BOLD, further studies are warranted to clarify the vascular origin of our findings.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords