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Abstract #0498

On the variability of single-point MPF mapping in the human brain using different Variable Flip Angle T1 mapping protocols

Lucas Soustelle1,2, Thomas Troalen3, Andreea Hertanu1,2, Maxime Guye1,2, Jean-Philippe Ranjeva1,2, Guillaume Duhamel1,2, and Olivier M. Girard1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Siemens Healthcare SAS, Saint-Denis, France

Fast macromolecular proton fraction (MPF) mapping based on single-point (SP) quantitative MT method has shown great promises for the evaluation of myelin-related studies while allowing for acceptable scan times. The SP method requires a T1 map, which is inherently biased by magnetization transfer effects. In this work, we investigate the effect of T1 maps derived from different Variable Flip Angle (VFA) protocols on the computed MPF maps. It is shown that VFA-T1 is highly variable because of MT effects, hence biasing SP-MPF maps values. The SP-MPF methodology should therefore consider MT effects in VFA-T1 estimation, especially for cross-vendor applications.

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