Abstract #0505

A free-running cardiac T1* mapping sequence for quantifying dynamic changes in myocardial T1* at rest and physiological exercise

Rui Guo¹, Haikun Qi², Xiaoying Cai^1,3, Selcuk Kucukseymen¹, Hassan Haji-Valizadeh¹, Jennifer Rodriguez¹, Amanda Paskavitz¹, Patrick Pierce¹, Beth Goddu¹, Richard B. Thompson⁴, and Reza Nezafat¹

¹Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, BOSTON, MA, United States, ²School of Biomedical Engineering and Imaging Sciences, London, United Kingdom, ³Siemens Medical Solutions USA, Inc, Boston, MA, United States, ⁴University of Alberta, Department of Biomedical Engineering, Edmonton, MA, Canada

In this study, we developed a free-running cardiac T₁^* mapping sequence (DELTA) for quantifying the dynamic changes in myocardial T₁^*in response to physiological exercise. DELTA adopts continuous radial acquisition, self-navigation, and adaptive acquisition window to address the challenges associated with high heart rate and deep breathing after exercise. Phantom T₁^* by DELTA was heart-rate insensitive and had good repeatability. In vivo T₁^* among multiple measurements had little variation and comparable precision with MOLLI5(3)3 T₁^*.In the stress/rest studies, T₁^*reactivity was larger during the first scan after exercise and gradually reduced along the duration of post-exercise.

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