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Abstract #0509

MB-SWIFT fMRI studies in head-fixed behaving rats

Jaakko Paasonen1, Petteri Stenroos1,2, Hanne Laakso1, Tiina Pirttimäki1, Ekaterina Zhurakovskaya1, Raimo A Salo1, Heikki Tanila1, Djaudat Idiyatullin3, Michael Garwood3, Shalom Michaeli3, Silvia Mangia3, and Olli Gröhn1
1A.I.V. Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 2Grenoble Institut des Neurosciences, Grenoble, France, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Currently there are no tools to study simultaneously whole-brain processing and behavior in rats. Here we introduce a novel approach for fMRI studies in head-fixed and minimally restrained rats that can express behavior. This was achieved with MB-SWIFT sequence that is both quiet and insensitive to movement. First, the whole brain, including hindbrain, was functionally parcellated with high fidelity. Second, fMRI maps showing activation in relevant networks during spontaneous single behavioral events were successfully generated. Our approach links global network activity to behavior and has potential to enable novel experimental designs in neuroscience studies.

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