Abstract #0509

MB-SWIFT fMRI studies in head-fixed behaving rats

Jaakko Paasonen¹, Petteri Stenroos^1,2, Hanne Laakso¹, Tiina Pirttimäki¹, Ekaterina Zhurakovskaya¹, Raimo A Salo¹, Heikki Tanila¹, Djaudat Idiyatullin³, Michael Garwood³, Shalom Michaeli³, Silvia Mangia³, and Olli Gröhn¹

¹A.I.V. Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ²Grenoble Institut des Neurosciences, Grenoble, France, ³Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Currently there are no tools to study simultaneously whole-brain processing and behavior in rats. Here we introduce a novel approach for fMRI studies in head-fixed and minimally restrained rats that can express behavior. This was achieved with MB-SWIFT sequence that is both quiet and insensitive to movement. First, the whole brain, including hindbrain, was functionally parcellated with high fidelity. Second, fMRI maps showing activation in relevant networks during spontaneous single behavioral events were successfully generated. Our approach links global network activity to behavior and has potential to enable novel experimental designs in neuroscience studies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.