The morphologic MR imaging is limited in identifying sub-voxel sized cartilage defect due to partial volume averaging. We assessed the feasibility of synovial fluid fraction (SFF) map generated by multicomponent approach using MRF-derived relaxation maps to characterize sub-voxel sized cartilage defect. In ex vivo experiment, we proved that SFF map can quantify synovial fluid fraction in sub-voxel sized cartilage defects. In clinical study, we demonstrated that SFF map can complement morphologic imaging in cartilage segmentation and volumetric assessment.
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