Abstract #0535

Utility of Texture Analysis on Quantitative Susceptibility Maps to Stage Hepatic Fibrosis

FengLing Gan¹, Shuohui Yang², Feng Xing³, Zheng Qu¹, Gaiying Li¹, Chenyao Yang², Rongfang Guo², Jiling Huang², Fang Lu², Caixia Fu⁴, Xu Yan⁴, Kelly Gillen⁵, Yi Wang⁵, Chenghai Liu³, Songhua Zhan², and Jianqi Li¹

¹Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, shanghai, China, ²Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, shanghai, China, ³Department of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, shanghai, China, ⁴MR Collaboration NE Asia, Siemens Healthcare, shanghai, China, ⁵Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States

Hepatic fibrosis is characterized by excessive accumulation of extracellular matrix (ECM) proteins including collagen, which would contribute strong diamagnetic susceptibility in the liver tissue due to enhanced density of orbiting electrons. This study measured the texture features on susceptibility maps in patients with chronic liver diseases. The results showed that some of the second-order texture parameters were significantly different between cohorts of significant hepatic fibrosis (Ishak-F ≥ 3) and non-significant hepatic fibrosis (Ishak-F < 3). The texture analysis on susceptibility maps may have the potential to stage hepatic fibrosis.

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