Abstract #0547

Dysfunction of Olfactory Resting-State Functional network in Early-onset Early-stage Parkinson’s Disease

Jianli Wang¹, Rachel Stanford¹, Lauren Spreen², Jeffrey Vesek², Christopher Sica¹, Thyagarajan Subramanian³, and Qing X Yang⁴

¹Radiology, Penn State College of Medicine, HERSHEY, PA, United States, ²Molecular Biology, Penn State College of Medicine, HERSHEY, PA, United States, ³Neurology, Penn State College of Medicine, HERSHEY, PA, United States, ⁴Neurosurgery, Penn State College of Medicine, HERSHEY, PA, United States

Hyposmia is prevalent in Parkinson’s disease (PD) and the central olfactory system is highly affected by PD pathology. Despite the considerable progresses in understanding the pathophysiology of the disease, the mechanism causing hyposmia in PD is still unclear. Given that there is early PD-related neurodegeneration in anterior olfactory nucleus, which is a part of the primary olfactory cortex, we tested the hypothesis that there are PD-related dysfunctions in the central olfactory functional network at the early stage of disease.

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