Diﬀuse intrinsic pontine glioma (DIPG) is a pediatric brain tumor with very poor prognosis. In this study, we identify two subtypes of DIPG based on radiomic features. The two subtypes show a signiﬁcant diﬀerence in survival rates. Subtype 1 has a mean progression-free survival (PFS) and overall survival (OS) of 8.9 and 12.7 months, respectively. Subtype 2 has a mean PFS and OS of 5.7 and 9.1 months, respectively. Our results suggest that shape features and intensity features extracted from FLAIR and T1-post contrast predict the prognosis of DIPG.