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Abstract #0609

Six-Dimensional, Free-Breathing Multitasking Multi-Echo (MT-ME) MRI for Whole-Liver T1, PDFF, and R2* Quantification

Nan Wang1, Tianle Cao1,2, Fei Han3, Yibin Xie1, Xiaodong Zhong3, Sen Ma1, Xinheng Zhang1,2, Xiaoming Bi3, Mazen Noureddin4, Vibhas Deshpande3, Anthony G Christodoulou1, and Debiao Li1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, 4Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Chronic liver disease has been a leading cause of mortality worldwide. Multiparametric MRI is a promising tool for non-invasive characterization of liver disease, but has yet to be widely used in clinical practice due to demanding technical challenges. In this work, we proposed a 6D Multitasking multi-echo (MT-ME) technique that allows free-breathing acquisition, whole-liver coverage, and simultaneous T1, PDFF, R2*, and water-specific T1 (T1w) quantification. Phantom study and in vivo studies with 14 volunteers and 1 patient with NAFLD were performed. The quantitative parameters measured from MT-ME were repeatable and showed good agreement with the reference methods.

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