Abstract #0609

Six-Dimensional, Free-Breathing Multitasking Multi-Echo (MT-ME) MRI for Whole-Liver T1, PDFF, and R2* Quantification

Nan Wang¹, Tianle Cao^1,2, Fei Han³, Yibin Xie¹, Xiaodong Zhong³, Sen Ma¹, Xinheng Zhang^1,2, Xiaoming Bi³, Mazen Noureddin⁴, Vibhas Deshpande³, Anthony G Christodoulou¹, and Debiao Li¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, ⁴Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Chronic liver disease has been a leading cause of mortality worldwide. Multiparametric MRI is a promising tool for non-invasive characterization of liver disease, but has yet to be widely used in clinical practice due to demanding technical challenges. In this work, we proposed a 6D Multitasking multi-echo (MT-ME) technique that allows free-breathing acquisition, whole-liver coverage, and simultaneous T1, PDFF, R2*, and water-specific T1 (T1_w) quantification. Phantom study and in vivo studies with 14 volunteers and 1 patient with NAFLD were performed. The quantitative parameters measured from MT-ME were repeatable and showed good agreement with the reference methods.

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