Abstract #0611

Free-Breathing, Confounder Corrected T1 Mapping in the Liver with Stack-of-Stars Inversion Recovery MRI

Yavuz Muslu^1,2, Ty A. Cashen³, Sagar Mandava⁴, and Scott B. Reeder^1,2,5,6,7

¹Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Global MR Applications and Workflow, GE Healthcare, Madison, WI, United States, ⁴Global MR Applications and Workflow, GE Healthcare, Atlanta, GA, United States, ⁵Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁷Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Quantitative T1 mapping in the liver is an emerging biomarker of hepatic fibrosis and characterization of liver function. The variable flip angle approach with Cartesian sampling is among the most popular T1 mapping methods used in the abdomen. A major drawback of this approach is that T1 estimations are highly sensitive to B1 inhomogeneities. Furthermore, Cartesian sampling suffers from motion related ghosting artifacts and requires breath-holding acquisitions. In this study, we propose to combine stack-of-stars radial sampling with dual-echo inversion recovery (IR-SoS) MRI for confounder corrected T1 mapping in the abdomen.

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