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Abstract #0618

Fast T2-mapping in prostate cancer based on echo-time domain compressed sensing

Jochen Keupp1, Petra J. v. Houdt2, Jakob Meineke1, Paul de Bruin3, Johannes M. Peeters3, Leon ter Beek4, and Mariya Doneva1
1Philips Research, Hamburg, Germany, 2Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands, 3Philips Healthcare, Best, Netherlands, 4Department of Medical Physics, The Netherlands Cancer Institute, Amsterdam, Netherlands

T2w-MRI plays an important role in prostate cancer providing information on the location and aggressiveness in diagnosis and therapy. T2-mapping may provide objective characterization, but is hampered by long acquisition time, which has been addressed by dedicated acceleration techniques (e.g. k-t T2-mapping). We investigated T2-mapping in a prostate cancer patient based on a 4-minute protocol with Poisson-disk prospective irregular sub-sampling in the ky-TE domain in combination with a low rank and sparsity constraint compressed sensing reconstruction. The regularization parameters were investigated, and compressed sensing results were compared to separately acquired k-t T2-maps with respect to quality and noise.

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