Abstract #0628

Disposable Point-of-care Portable Perfusion Phantom for Accurate Quantitative DCE-MRI

Martin Dawson Holland¹, Andres Morales¹, Sean Simmons², Brandon Smith¹, Samuel R Misko¹, Roy P Koomullil¹, Junzhong Xu³, David A Hormuth, II⁴, Junzhong Xu³, Thomas E Yankeelov⁴, and Harrison Kim¹

¹University of Alabama at Birmingham, Birmingham, AL, United States, ²Objective Design, Birmingham, AL, United States, ³Vanderbilt University Medical Center, Nashville, TN, United States, ⁴University of Texas, Austin, TX, United States

A new point-of-care portable perfusion phantom was developed to reduce inter- and intra-scanner variability of quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). This device is disposable, easily operable, and conveniently deliverable for widespread, routine clinical use. As this device has high repeatability (intraclass correlation coefficient = 0.997), it can be utilized to improve the accuracy of quantitative DCE-MRI based analysis of many diseases including cancer.

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