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Abstract #0634

Double spin-echo EPI improves sensitivity and specificity for cortical depth-dependent BOLD fMRI in the human somatosensory cortex at 7 T

SoHyun Han1,2, HyungJoon Cho3, Kâmil Uludaǧ1,2, and Seong-Gi Kim1,2
1Center for Neuroscience Imaging Research, Suwon, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 3Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of

Spatial-specificity is important for high spatial-resolution-fMRI to determine neuronal activity laminar-profiles. GE-BOLD-signals have low specificity because the highest signals originate from draining-veins at the surface of the cortex, not from capillaries nearby active neurons. However, SE-BOLD-signal has been proposed to be a better indicator of the location of neural activity. In this study, double SE-EPI-sequence was developed to achieve increased sensitivity in SE-BOLD-fMRI and demonstrated its feasibility for fMRI with 0.8-mm in-plane resolution. The results confirm that dSE-BOLD has higher specificity than GE-BOLD and better sensitivity than conventional-SE-BOLD and its potential to probe the function of cortical-circuits with high specificity.

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