Spatial-specificity is important for high spatial-resolution-fMRI to determine neuronal activity laminar-profiles. GE-BOLD-signals have low specificity because the highest signals originate from draining-veins at the surface of the cortex, not from capillaries nearby active neurons. However, SE-BOLD-signal has been proposed to be a better indicator of the location of neural activity. In this study, double SE-EPI-sequence was developed to achieve increased sensitivity in SE-BOLD-fMRI and demonstrated its feasibility for fMRI with 0.8-mm in-plane resolution. The results confirm that dSE-BOLD has higher specificity than GE-BOLD and better sensitivity than conventional-SE-BOLD and its potential to probe the function of cortical-circuits with high specificity.
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