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Abstract #0653

Correlating advanced MRI and histopathological measurements of axons and myelin in human traumatic spinal cord injury

Sarah Rosemary Morris1,2,3, Andrew Yung1,2,4, Valentin Prevost1,2,4, Shana George1, Andrew Bauman1,2,4, Piotr Kozlowski1,2,3,4, Farah Samadi1,5, Caron Fournier1,5, Lisa Parker6, Kevin Dong1, Femke Streijger1, Veronica Hirsch-Reinshagen1,5,6, G.R. Wayne Moore1,5,6, Brian K Kwon1,7, and Cornelia Laule1,2,3,5
1International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada, 3Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 4UBC MRI Research Centre, Vancouver, BC, Canada, 5Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 6Vancouver General Hospital, Vancouver, BC, Canada, 7Vancouver Spine Surgery Institute, Vancouver, BC, Canada

Using human spinal cord tissue donated to the International Spinal Cord Injury Biobank, we quantitatively correlated binarized histological stains for myelin and axons with myelin- and axon-sensitive advanced MRI metrics (myelin water fraction (MWF), inhomogeneous magnetization transfer (ihMT), diffusion tensor imaging (fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity, RD), diffusion basis spectrum imaging (fibre fraction, FF)). MWF, ihMT and RD had significant, moderately strong correlations with Luxol fast blue staining for myelin phospholipids. FA, AD and FF did not have any significant correlation with phosphorylated neurofilament immunohistochemistry.

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