Abstract #0655

Associations between cervical cord sodium concentration, neuronal density and macromolecular tissue volume in spinal cord injury

Bhavana S Solanky¹, Ferran Prados^1,2, Francesco Grussu^1,3, Marco Battiston¹, Jon Stutters¹, Selma Al-Ahmad⁴, Baris Kanber², David Choi⁴, Jalesh Panicker⁵, and Claudia AM Gandini Wheeler-Kingshott^1,6,7

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, United Kingdom, ²Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, ³Radiomics Group, Vall d’Hebron Institute of Oncology, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, ⁴National Hospital For Neurology and Neurosurgery, London, United Kingdom, ⁵Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery and UCL Queen Square Institute of Neurology, London, United Kingdom, ⁶Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, ⁷Brain Connectivity Centre Research Department, IRCCS Mondino Foundation, Pavia, Italy

Sodium retention as a consequence of spinal cord injury is thought to impair the regenerative ability of neurons but also reduce damage. Pilot studies suggest a possible increase in total sodium concentration (TSC) in spinal cord injury. Here we report increases in spinal cord TSC in cervical myelopathy patients relative to healthy controls. Given that the increase could be a consequence of intracellular accumulation of sodium or increases in extracellular sodium through enlarged extracellular space, the correlations of sodium with microstructure were investigated using neurite orientation dispersion and density imaging (NODDI) and macromolecular tissue volume imaging.

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