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Abstract #0657

Detection of fine-scale functional networks in spinal cord and the effects of injury on intra- and inter-segmental networks

Anirban Sengupta1, Arabinda Mishra1, Feng Wang1, Li Min Chen1, and John C. Gore1
1Vanderbilt University Medical Center, Nashville, TN, United States

The objective of this study was to identify fine-scale resting state functional networks within the spinal cord gray matter of squirrel monkeys, and measure the changes in functional connectivity within the cord after a targeted injury. Independent Component Analysis of resting state fMRI data detected robust BOLD signals localized at the bilateral intermediate and gray-commissure regions of the spinal cord as well at the ‘4 horns’. A unilateral section of dorsal column tract at C5 segment of spinal cord damaged the inter-segmental connectivity more than intra-segmental connectivity, as observed through individual connectivity measures and community structures generated by graph-theory principles.

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