Meeting Banner
Abstract #0665

Left-Right Intensity Asymmetries Systematically Vary Across MR Scanners and Introduce Diagnostic Uncertainty

Arvin Arani1, Christopher G. Schwarz1, Matthew C. Murphy1, Joshua D. Trzasko1, Jeffrey L. Gunter1, Matthew L. Senjem1, Heather J. Wiste1, Kiaran P. McGee1, Matthew A. Bernstein1, John Huston III1, and Clifford R. Jack Jr.1
1Mayo Clinic, Rochester, MN, United States

In magnetic resonance imaging (MRI) many factors can contribute to non-tissue specific image intensity inhomogeneity. However, the potential clinical impact or systematic biases of these effects have not been extensively investigated across multiple MRI vendors and models for neuroimaging applications. Specifically, left-right intensity comparisons are commonly used by radiologists to verify/identify pathology. If significant systematic left-right intensity asymmetries (LRIA) exist, it may lead to diagnostic uncertainty and result in unnecessary imaging follow-up and patient burden. This study shows that LRIA are common, system specific, systematic, can mimic disease, create diagnostic uncertainty, and can impact multiple sequences (T1-weighted and FLAIR).

This abstract and the presentation materials are available to members only; a login is required.

Join Here