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Abstract #0672

Laser Heating Induced Susceptibility Artifacts Cause Significant Temperature Erros in PRF Shift-based MR Thermometry

Ziyi Pan1, Meng Han2, Yawei Kuang2, Hao Sun2, Kai Zhang3, Yuan Lian1, Yishi Wang4, Wenbo Liu2, Guangzhi Wang5, and Hua Guo1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Sinovation Medical, Beijing, China, 3Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 4Philips Healthcare, Beijing, China, 5Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China

MR-guided laser-interstitial thermal therapy (MRgLITT) is a minimally invasive therapeutic method that has created new options for surgically challenging lesions. Most MRgLITT procedures depend on proton-resonance-frequency (PRF) shift-based MR thermometry. However, it can be hampered by magnetic susceptibility changes generated during laser ablation. In this work, we demonstrate for the first time that laser-heating induced susceptibility changes can lead to significant temperature errors, with ex-vivo (pig muscle and brain tissues), in-vivo (Doberman) and clinical (epilepsy patient) experiments. A new algorithm based on multi-echo GRE instead of the conventional single-echo GRE is also introduce to correct the susceptibility-induced temperature errors.

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