Abstract #0672

Laser Heating Induced Susceptibility Artifacts Cause Significant Temperature Erros in PRF Shift-based MR Thermometry

Ziyi Pan¹, Meng Han², Yawei Kuang², Hao Sun², Kai Zhang³, Yuan Lian¹, Yishi Wang⁴, Wenbo Liu², Guangzhi Wang⁵, and Hua Guo¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²Sinovation Medical, Beijing, China, ³Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁴Philips Healthcare, Beijing, China, ⁵Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China

MR-guided laser-interstitial thermal therapy (MRgLITT) is a minimally invasive therapeutic method that has created new options for surgically challenging lesions. Most MRgLITT procedures depend on proton-resonance-frequency (PRF) shift-based MR thermometry. However, it can be hampered by magnetic susceptibility changes generated during laser ablation. In this work, we demonstrate for the first time that laser-heating induced susceptibility changes can lead to significant temperature errors, with ex-vivo (pig muscle and brain tissues), in-vivo (Doberman) and clinical (epilepsy patient) experiments. A new algorithm based on multi-echo GRE instead of the conventional single-echo GRE is also introduce to correct the susceptibility-induced temperature errors.

This abstract and the presentation materials are available to members only; a login is required.

Join Here