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Abstract #0700

Ex vivo and In vivo Diffusion Weighted MRI highlights the Microarchitecture of mouse Pancreatic Intraepithelial Neoplasia

Carlos Bilreiro1,2, Francisca F Fernandes1, Rui V Simões1, Mireia Castillo-Martin1,3, Andrada Ianus1, Cristina Chavarrias1, Celso Matos1,2, and Noam Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Department of Radiology, Champalimaud Clinical Centre, Lisbon, Portugal, 3Department of Pathology, Champalimaud Clinical Centre, Lisbon, Portugal

As current therapeutic options for pancreatic cancer are mostly ineffective, developing diagnostic tools for early detection of precursor lesions (mainly pancreatic intraepithelial neoplasia – PanIN) could change the course of this disease. Here, we investigated Diffusion-MRI (dMRI) contrasts for this purpose, using transgenic mouse models. First, we performed ex vivo dMRI Microscopy at ultrahigh field with histological validation, defining the most sensitive contrasts. Then, we performed in vivo abdominal imaging, demonstrating their applicability in the non-invasive study of PanIN and pancreatic cancer. These findings provide new tools for researching PanIN and hold promise for a future translation to clinical practice.

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