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Abstract #0702

Diffusion MRI study of chemoradiation treatment response in patients with HPV positive oropharyngeal carcinoma

Sungheon Gene Kim1, Mehran Baboli1, Justin Fogarty2, Steven H. Baete2, Joseph Kim3, Paulina Galavis3, Moses Tam3, Kenneth Hu3, and Elcin Zan2
1Radiology, Weill Cornell Medical College, New York, NY, United States, 2Radiology, New York University School of Medicine, New York, NY, United States, 3Radiation Oncology, New York University School of Medicine, New York, NY, United States

In this study, we evaluated diffusion and kurtosis time-dependence for HPV-positive oropharyngeal squamous cell carcinoma before and during chemo-radiation treatment over a wide range for longer diffusion times (200-700 ms). The patients with less than 40% nodal volume shrinkage had significantly higher diffusivity at pretreatment and lower kurtosis at week4 than the patients with more than 40% nodal volume shrinkage. The water exchange times were 68-80 ms without a significant difference between the groups. This study demonstrates the feasibility of using diffusion MRI at relatively long diffusion times to predict and evaluate the response to chemo-radiation therapy.

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