Abstract #0712

Quantifying Placental Structure and Function in Healthy and Compromised Pregnancies with Combined T2*-diffusion

Paddy J. Slator¹, Jana Hutter^2,3, Razvan V. Marinescu¹, Marco Palombo¹, Laurence Jackson^2,3, Alison Ho⁴, Lucy C Chappell⁴, Mary Rutherford², Joseph V Hajnal^2,3, and Daniel Alexander¹

¹Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ²Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁴Women’s Health Department, King's College London, London, United Kingdom

We quantify placental structure and function across gestation using a combined T2*-diffusion protocol and InSpect, a data-driven approach for quantitative MRI analysis. We identify and map seven distinct placental tissue environments, and show that these environments are related to dysfunction. Our approach shows promise for diagnosis and monitoring of pregnancy complications.

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