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Abstract #0741

Cost-Effectiveness Analysis of Magnetic Resonance Spectroscopy for the Differentiation of Recurrent Glioma from Radiation Necrosis

Huijun Liao1, So Wing Lum1, and Alexander P. Lin1
1Center for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, United States

To date there have been no formal studies of the cost-effectiveness of magnetic resonance spectroscopy. Cost-effectiveness analysis was conducted by utilizing a decision-analytic model that compared MRS and standard of care to standard of care alone for recurrent glioma and necrosis differentiation. Our results showed that performing MRS was highly cost-effective with incremental cost-effectiveness ratios of -$98,978, -$50,666 and -$41,349 per quality-adjusted life-years over 5-year, 10-year and lifetime horizons. At the willingness-to-pay threshold of $50,000, performing MRS was more cost-effective with certainty of 96% to 97% over those time-horizons. MRS should be considered reimbursable by policy makers.

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