Meeting Banner
Abstract #0743

Assessing breast density using the standardized proton density fat fraction based on chemical shift encoding-based water-fat separation 

Tabea Borde1, Mingming Wu1, Stefan Ruschke1, Christof Böhm1, Kilian Weiss2, Stephan Metz1, Marcus R Makowski1, and Dimitrios Karampinos1
1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 2Philips Healthcare, Hamburg, Germany

Breast density is confirmed as a strong, independent risk factor of breast cancer which is why there is a clinical need for a robust, reader-independent, non-ionizing, quantitative assessment of breast density. This retrospective study proposes the proton density fat fraction (PDFF) derived from chemical shift encoding-based water-fat separation as a novel quantitative MRI biomarker of breast density. As a clinically highly practicable biomarker that is automatedly obtainable and insensitive to acquisition parameters and the partial volume effect, the PDFF significantly negatively correlated with the most commonly used conventional radiographic mammogram breast density estimations.

This abstract and the presentation materials are available to members only; a login is required.

Join Here