Abstract #0752

Lipid droplet size mapping in human adipose tissue using a clinical 3 T system

Dominik Weidlich¹, Julius Honecker², Christof Boehm¹, Stefan Ruschke¹, Daniela Junker¹, Anh Van¹, Marcus Makowski¹, Christina Holzapfel³, Melina Claussnitzer^4,5,6, Hans Hauner^2,3, and Dimitrios C. Karampinos¹

¹Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, ²Else Kröner Fresenius Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Munich, Germany, ³Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany, ⁴Broad Institute of MIT and Harvard, Cambridge, MA, United States, ⁵Beth Israel Deaconess Medical Center, Boston, MA, United States, ⁶Harvard Medical School, Harvard University, Boston, MA, United States

Despite its high relevance in metabolic research, the non-invasive measurement of adipocyte size remains an unmet need. DW-MRS has been previously applied to probe diffusion restriction effects in vivo to measure lipid droplets in animals up to diameters of 10 µm and in humans up to diameters of 50 µm. However, DW-MRS suffers from signal loss due to intravoxel-dephasing even when minimal motion is present. This work proposes a novel DW-MRI sequence and diffusion signal processing. In simulations and ex vivo adipose tissue measurements, the presented method results show agreement with ground truth and histology in measuring lipid droplet size.

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