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Abstract #0759

Prediction of prognosis after definitive radiotherapy for uterine cervical cancer using changes of ADC histogram during the clinical course

Akiyo Takada1, Hajime Yokota2, Miho Watanabe Nemoto2, Takuro Horikoshi1, Koji Matsumoto1, Yuji Habu3, Hirokazu Usui3, Katsuhiro Nasu1, Makio Shozu3, and Takashi Uno2
1Radiology, Department of Radiology, Chiba University Hospital, Chiba, Japan, 2Radiology, Department of Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan, 3Obstetrics and gynecology, Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan

To realize precision medicine for cervical cancer, it is essential to predict the prognosis. We focused on changes in ADC histogram during the clinical course. Sixty-eight patients were included and they underwent MRI evaluation 4 times during the clinical course. Imaging features were extracted from the ADC histogram in the whole tumor VOI and their change rates were calculated. The change rates of kurtosis between the first and third, and between the first and second imaging could predict recurrence with high AUCs (0.90 and 0.83). By predicting the prognosis early during clinical course, a more personalized treatment can be provided.

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