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Abstract #0764

Improving Multiparametric MR - TRUS Guided Fusion Prostate Biopsies with Hyperpolarized 13C Pyruvate Metabolic Imaging : Technical Development

Hsin-Yu Chen1, Robert A. Bok1, Hao G. Nguyen2, Katsuto Shinohara2, Antonio C. Westphalen1, Zhen J. Wang1, Michael A. Ohliger1, Lucas Carvajal1, Jeremy W. Gordon1, Peder E.Z. Larson1, Rahul Aggarwal2, John Kurhanewicz1, and Daniel B. Vigneron1
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States

This project developed a new approach of integrating research biopsy targets, defined by metabolic abnormalities on hyperpolarized (HP) 13C pyruvate MRI, into clinical multiparametric MRI workflow to guide software-fusion transrectal ultrasound (TRUS) biopsy for improved prostate cancer risk stratification. Feasibility was investigated in 3 prostate cancer patient studies, for which research biopsy targets corresponding to high pyruvate-to-lactate conversion rates (kPL) were identified and outlined by experienced abdominal radiologists. Fusion biopsies identified histologically-confirmed cancer at two out of three “C13” targets, consistent with clinically low- to intermediate-risk disease, supporting continued active surveillance management for these patients.

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