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Abstract #0766

In-vivo Magnetic Resonance Elastography of implanted human prostate tumors in a murine model.

Joachim Snellings1, Kader Avan1, Marcus Markowski2, Bernd Hamm1, Patrick Asbach1, Carsten Warmuth1, Mehrgan Shahryari1, Heiko Tzschätzsch1, Ingolf Sack1, and Jürgen Braun3
1Institute of Radiology, Charité Üniversitätsmedizin, Berlin, Germany, 2School of Medicine & Klinikum Rechts der Isar, Technical University of Munich, Munich (TUM), München, Germany, 3Institut für Medizinische Informatik, Charité Üniversitätsmedizin, Berlin, Germany

Prostate cancer (PCa) is the second leading cause of cancer-death in men in the western world. Advanced techniques of clinical MR-elastography (MRE), allow the characterization of PCa, based on the viscoelastic tissue-properties, which provide rich biophysical signatures of tumor progression. Using multifrequency MRE, we investigated PCa introduced LNCaP cell-lines, in a immunodeficient murine model, in-vivo, in a 3-Tesla MRI-scanner and, ex-vivo, by a 0.5-Tesla compact MRE-device. In-vivo and ex-vivo MRE values of LNCaP were in good agreement given the viscoelastic frequency-dispersion typical for soft-tissues. Compared with patient data in literature, LNCaP in mice are softer than PCa in humans.

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