Prostate cancer (PCa) is the second leading cause of cancer-death in men in the western world. Advanced techniques of clinical MR-elastography (MRE), allow the characterization of PCa, based on the viscoelastic tissue-properties, which provide rich biophysical signatures of tumor progression. Using multifrequency MRE, we investigated PCa introduced LNCaP cell-lines, in a immunodeficient murine model, in-vivo, in a 3-Tesla MRI-scanner and, ex-vivo, by a 0.5-Tesla compact MRE-device. In-vivo and ex-vivo MRE values of LNCaP were in good agreement given the viscoelastic frequency-dispersion typical for soft-tissues. Compared with patient data in literature, LNCaP in mice are softer than PCa in humans.
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