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Abstract #0768

Glucose oxidation rate as a potential marker for GBM staging: correlation with histopathology and cell proliferation in a mouse model

Rui V Simoes1, Rafael N Henriques1, Beatriz M Cardoso1, Tania Carvalho1, and Noam Shemesh1
1Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal

The dynamic interplay between cancer cells and their microenvironment impacts progression. We used dynamic glucose-enhanced deuterium MRS (DGE 2H-MRS) to investigate the association between functional metabolic heterogeneity and cell proliferation in a syngeneic mouse model of GBM. Taking a stepwise approach, from cell culture studies to in vivo mouse MRI/MRS and post-mortem analysis, our results suggest a potential role for glucose oxidation rate as a marker of cell proliferation and vascular stability. Extending this methodology to other GBM models and/or molecular subtypes could create new opportunities for non-invasive phenotyping of the disease.

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