Abstract #0789

Quantitative mapping of susceptibility and non-susceptibility frequency with DEEPOLE QUASAR

Thomas Jochmann¹, Dejan Jakimovski², Nora Küchler¹, Robert Zivadinov^2,3, Jens Haueisen¹, and Ferdinand Schweser^2,3

¹Department of Computer Science and Automation, Technische Universität Ilmenau, Ilmenau, Germany, ²Buffalo Neuroimaging Analysis Center, Department of Neurology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States

Besides magnetic susceptibility, MRI phase contrast is caused by chemical exchange, anisotropic magnetic susceptibility, and anisotropic microstructural compartmentalization. These additional contributions are neglected by conventional QSM. This work presents an improved version of DEEPOLE QUASAR, a phase processing method that accounts for non-susceptibility signal contributions. We present preliminary results from studies on mice, volunteers, and multiple sclerosis (MS) patients.

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