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Abstract #0789

Quantitative mapping of susceptibility and non-susceptibility frequency with DEEPOLE QUASAR

Thomas Jochmann1, Dejan Jakimovski2, Nora K├╝chler1, Robert Zivadinov2,3, Jens Haueisen1, and Ferdinand Schweser2,3
1Department of Computer Science and Automation, Technische Universit├Ąt Ilmenau, Ilmenau, Germany, 2Buffalo Neuroimaging Analysis Center, Department of Neurology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 3Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States

Besides magnetic susceptibility, MRI phase contrast is caused by chemical exchange, anisotropic magnetic susceptibility, and anisotropic microstructural compartmentalization. These additional contributions are neglected by conventional QSM. This work presents an improved version of DEEPOLE QUASAR, a phase processing method that accounts for non-susceptibility signal contributions. We present preliminary results from studies on mice, volunteers, and multiple sclerosis (MS) patients.

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