Abstract #0821

Accelerated Diffusion-Relaxation Correlation Spectrum Imaging (DR-CSI) for Ex Vivo and In Vivo Prostate Microstructure Mapping

Zhaohuan Zhang¹, Sohrab Afshari Mirak¹, Melina Hosseiny¹, Afshin Azadikhah¹, Amirhossein Mohammadian Bajgiran¹, Alan Priester², Kyunghyun Sung¹, Anthony Sisk³, Robert Reiter², Steven Raman¹, Dieter Enzmann¹, and Holden Wu¹

¹Department of Radiological Sciences, UCLA, Los Angeles, CA, United States, ²Department of Urology, UCLA, Los Angeles, CA, United States, ³Department of Pathology, UCLA, Los Angeles, CA, United States

Diffusion-relaxation correlation spectrum imaging (DR-CSI) can map prostate microstructure in both ex vivo and in vivo imaging. However, the translation of prostate DR-CSI to in vivo applications faces technical challenges regarding trade-offs between scan time and accuracy. The goal of this study was to develop a data-driven systematic framework to evaluate and select subsampled DR-CSI echo time and b-values encoding schemes that reduce scan time while maintaining accuracy of estimated prostate microstructure parameters.

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