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Abstract #0821

Accelerated Diffusion-Relaxation Correlation Spectrum Imaging (DR-CSI) for Ex Vivo and In Vivo Prostate Microstructure Mapping

Zhaohuan Zhang1, Sohrab Afshari Mirak1, Melina Hosseiny1, Afshin Azadikhah1, Amirhossein Mohammadian Bajgiran1, Alan Priester2, Kyunghyun Sung1, Anthony Sisk3, Robert Reiter2, Steven Raman1, Dieter Enzmann1, and Holden Wu1
1Department of Radiological Sciences, UCLA, Los Angeles, CA, United States, 2Department of Urology, UCLA, Los Angeles, CA, United States, 3Department of Pathology, UCLA, Los Angeles, CA, United States

Diffusion-relaxation correlation spectrum imaging (DR-CSI) can map prostate microstructure in both ex vivo and in vivo imaging. However, the translation of prostate DR-CSI to in vivo applications faces technical challenges regarding trade-offs between scan time and accuracy. The goal of this study was to develop a data-driven systematic framework to evaluate and select subsampled DR-CSI echo time and b-values encoding schemes that reduce scan time while maintaining accuracy of estimated prostate microstructure parameters.

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