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Abstract #0889

3D choline metabolite imaging in the liver by MRSI with selective excitation using spectral-spatial RF pulses at 7T

Lieke van den Wildenberg1, Arjan Hendriks1, Wybe van der Kemp1, Dennis Klomp1, and Jeanine Prompers1
1Radiology Department, UMC Utrecht, Utrecht, Netherlands

MR measurement of increased concentrations of choline containing compounds (tCho) in the liver could be used as a non-invasive tumor tissue biomarker. However, 3D 1H-MRSI with conventional water suppression and volume selection does not yield the sensitivity gain expected at higher fields like 7T. As a result, it cannot be performed in clinically feasible scan times with full coverage of the liver and at sufficient spatial resolution to detect tumor metastases. With spectral-spatial pulses, it is possible to spatially map tCho much faster and at higher SNR than with conventional MRSI, with excellent suppression of both water and lipid signals.

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