MR measurement of increased concentrations of choline containing compounds (tCho) in the liver could be used as a non-invasive tumor tissue biomarker. However, 3D 1H-MRSI with conventional water suppression and volume selection does not yield the sensitivity gain expected at higher fields like 7T. As a result, it cannot be performed in clinically feasible scan times with full coverage of the liver and at sufficient spatial resolution to detect tumor metastases. With spectral-spatial pulses, it is possible to spatially map tCho much faster and at higher SNR than with conventional MRSI, with excellent suppression of both water and lipid signals.
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