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Abstract #0915

Feasibility of a single low dose dual temporal resolution DCE-MRI method for whole-brain, high-spatial resolution parametric mapping

Ka-Loh Li1, Daniel Lewis2, David J Coope3, Federico Roncaroli3, Omar N Pathmanaban2, Andrew T King2, Sha Zhao1, Erjon Agushi1, Alan Jackson1, Timothy Cootes1, and Xiaoping Zhu1
1Division of Informatics, Imaging and Data Sciences, The University of Manchester, Manchester, United Kingdom, 2Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, United Kingdom, 3Division of Neuroscience and Experimental Psychology, The University of Manchester, Manchester, United Kingdom

This study sought to evaluate the feasibility of using a low gadolinium-based contrast agent (GBCA) dose protocol with a newly developed analysis technique, the LEGATOS method, for deriving whole-brain, high-spatial resolution pharmacokinetic parameters from dual-temporal resolution (DTR) DCE-MRI. Through Monte Carlo simulations and an in vivo study incorporating histopathological data the accuracy of pharmacokinetic parameters derived using a low-dose interleaved protocol and LEGATOS was assessed. Our results demonstrate that this approach permitted the derivation of accurate, tissue-validated high-spatial resolution kinetic parameter estimates following a single low-dose injection, representing in some patients a greater than 80% reduction in GBCA dose.

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