Abstract #0929

31P MRSI in tumor-bearing mice at 9.4T

Vanessa L. Franke¹, Justyna Platek¹, Philip S. Boyd¹, Stephanie Laier², Karin Mueller-Decker², Andrey Glinka³, Mark E. Ladd¹, Steffen Goerke¹, Peter Bachert¹, and Andreas Korzowski¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Center for Preclinical Research, Core Facility Tumor Models, German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Division of Molecular Embryology, German Cancer Research Center (DKFZ), Heidelberg, Germany

³¹P MRSI allows for the non-invasive investigation of energy metabolism in vivo and is therewith of interest for research on novel therapies for cancer. The purpose of this study was to investigate suitable acquisition strategies for ³¹P MRSI in tumor-bearing mice at B₀=9.4T in order to monitor in future studies effects of novel therapies affecting energy metabolism and pH values. ³¹P MRSI datasets with a spatial resolution of (2.5x2.5x7.5) mm³ obtained in 50 minutes enabled the quantification of signals in diseased tissue, while maintaining acceptable separation to healthy tissue.

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