Meeting Banner
Abstract #0931

Metabolomic Characterization of renal cell carcinoma patient-derived xenografts and derived Tissue Slice Cultures

Deepti Upadhyay1, Jinny Sun1, Joao Piraquive Agudelo1, Hongjuan Zhao2, Rosalie Nolley2, Robert Bok1, James D. Brooks2, Donna M. Peehl1, John Kurhanewicz1, and Renuka Sriram1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Urology, Stanford University, Stanford, CA, United States

NMR based stable isotope resolved metabolomics was used for the metabolic characterization of renal cell carcinoma (RCC) patient-derived xenografts (PDXs) and their derived tissue slice cultures (TSCs). Targeted metabolomics and [U-13C] glucose-labeling studies indicate metabolic heterogeneity among PDXs of various pathologic and clinical stages. Both PDXs and TSCs exhibit high glycolytic rate and low TCA activity characteristic of RCC. However, there is variability in glycolytic rate and TCA activity among different PDXs and their corresponding TSCs.

This abstract and the presentation materials are available to members only; a login is required.

Join Here