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Abstract #0934

Evaluating the utility of DCE-MRI in differentiating brain tumours using the extended Tofts and the Shutter Speed Model

Sourav Bhaduri1, Samantha Mills2, Mark Radon2, Michael Jenkinson3, and Harish Poptani1
1Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom, 2Department of Neuroradiology, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom, 3Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom

We demonstrate the potential utility of DCE-MRI derived pharmacokinetic parameters in differentiating brain tumour types using the extended Tofts and the Shutter Speed Model. Results show an increasing pattern in Ktrans, ve, vp estimates in GBM and metastasis compared to primary central nervous system lymphoma (PCNSL). The τi estimate in GBM was the lowest, while it was highest in PCNSL.

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