Abstract #0934

Evaluating the utility of DCE-MRI in differentiating brain tumours using the extended Tofts and the Shutter Speed Model

Sourav Bhaduri¹, Samantha Mills², Mark Radon², Michael Jenkinson³, and Harish Poptani¹

¹Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom, ²Department of Neuroradiology, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom, ³Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom

We demonstrate the potential utility of DCE-MRI derived pharmacokinetic parameters in differentiating brain tumour types using the extended Tofts and the Shutter Speed Model. Results show an increasing pattern in K^trans, v_e, v_p estimates in GBM and metastasis compared to primary central nervous system lymphoma (PCNSL). The τ_i estimate in GBM was the lowest, while it was highest in PCNSL.

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