Abstract #0936

Commonality and complexity of systemic metabolic dysregulation caused by cancer and cancer-induced cachexia

Santosh Kumar Bharti¹, Raj Kumar Sharma¹, Paul T Winnard¹, Marie-France Penet¹, and Zaver M. Bhujwalla^1,2,3

¹Div. of Cancer Imaging Research, The Russell H. Morgan Dept of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

In addition to anorexia, fat and muscle tissue wasting, psychological distress, lower tolerance to chemotherapy, and a poor quality of life, cachexia causes profound metabolic dysregulation in cancer patients that affects multiple organs. Here, for the first time, we have characterized metabolic changes in the spleen, liver, pancreas, lung, heart and kidney induced by pancreatic cancer xenografts to expand our understanding of the metabolic dysregulation caused by cachexia. These results highlight the systemic changes in metabolism that occur with cancer and with cancer induced cachexia that may lead to the development of early biomarkers as well to metabolic treatment strategies.

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