Abstract #0941

Using Variable Flip Angle (VFA) and Modified Look Locker Inversion Recovery (MOLLI) T1 Mapping in Clinical OE-MRI

Emma Bluemke¹, Ambre Bertrand¹, Kwun-Ye Chu^2,3, Nigar Syed², Andrew Murchison^3,4, Tessa Greenhalgh^3,5, Brian Burns⁶, Martin Craig⁷, Nia Taylor³, Ketan Shah^2,3, Fergus Gleeson^2,3, and Daniel Bulte¹

¹University of Oxford, Oxford, United Kingdom, ²MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, ³Radiotherapy Department, Oxford University Hospitals NHS, Oxford, United Kingdom, ⁴Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁵University Hospital Southampton NHS FT, Southhampton, United Kingdom, ⁶GE Healthcare, Menlo Park, CA, United States, ⁷University of Nottingham, Nottingham, United Kingdom

As clinical studies adopt Oxygen-Enhanced MRI to assess its feasibility in human tumours, it is important for researchers to report any practical complications experienced. We report our practical experience with using both MOLLI and VFA T1 mapping for a recently completed OE-MRI clinical oncology study with the aim that sharing this is helpful to researchers planning to use OE-MRI in clinical oncology. Specifically, we report 4 elements: (1) difference in estimated T1 from each method used (MOLLI and VFA), (2) standard deviation within tumour ROIs, (3) OE-MRI response resulting from either method, and (4) artefacts and practical difficulties encountered.

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