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Abstract #0941

Using Variable Flip Angle (VFA) and Modified Look Locker Inversion Recovery (MOLLI) T1 Mapping in Clinical OE-MRI

Emma Bluemke1, Ambre Bertrand1, Kwun-Ye Chu2,3, Nigar Syed2, Andrew Murchison3,4, Tessa Greenhalgh3,5, Brian Burns6, Martin Craig7, Nia Taylor3, Ketan Shah2,3, Fergus Gleeson2,3, and Daniel Bulte1
1University of Oxford, Oxford, United Kingdom, 2MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, 3Radiotherapy Department, Oxford University Hospitals NHS, Oxford, United Kingdom, 4Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 5University Hospital Southampton NHS FT, Southhampton, United Kingdom, 6GE Healthcare, Menlo Park, CA, United States, 7University of Nottingham, Nottingham, United Kingdom

As clinical studies adopt Oxygen-Enhanced MRI to assess its feasibility in human tumours, it is important for researchers to report any practical complications experienced. We report our practical experience with using both MOLLI and VFA T1 mapping for a recently completed OE-MRI clinical oncology study with the aim that sharing this is helpful to researchers planning to use OE-MRI in clinical oncology. Specifically, we report 4 elements: (1) difference in estimated T1 from each method used (MOLLI and VFA), (2) standard deviation within tumour ROIs, (3) OE-MRI response resulting from either method, and (4) artefacts and practical difficulties encountered.

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