Abstract #0946

The value of preoperative prediction of ki67 and P53 expression in DCE-MRI texture analysis of rectal cancer

Yuhui Liu¹, Ailian Liu¹, and Mingxiao Wang¹

¹The First Affiliated Hospital of Dalian Medical University, Dalian, China, Dalian, China

This study aims to analyze the intrinsic relationship between imaging indicators and tumor biological behavior, and improve the clinical value of DCE-MRI.The correlation between DCE-MRI quantitative parameter values (Ktrans, Ve, Kep) and molecular biomarkers (Ki67,P53) was compared and explored in patients with rectal cancer.(Ki67:the combined diagnostic performance is obtained,the AUC was 0.923, with the sensitivity of 90.5% and the specificity of 50%.P53:the combined diagnostic performance is obtained,the AUC was 0.737, with the sensitivity of 72.7% and the specificity of 66.7%.)

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