Cardiac mechanical performance of ALL survivors assessed by combined CMR and Incremental exercise test.

Despite the late development of cardiac dysfunction in childhood acute lymphoblastic leukemia survivors, early detection of doxorubicin-related cardiotoxicity remains a challenge to better stratify these survivors who need a close follow-up. Cine-CMR acquisitions, combined to cardiopulmonary exercise testing and CircAdapt simulations showed that survivors’ exposition to doxorubicin, whatever the cumulative dose received, affected the cardiac efficiency and the ventricular-arterial coupling at rest and for light cardiac stress. Moreover, dexrazoxane treatments helped survivors to better adapt to high cardiac stress while presenting no differences at rest and for light cardiac stress.