Abstract #0976

Impaired CMR-derived Pulmonary Artery Global Longitudinal Strain is Related to Decompensated Hemodynamics in Pulmonary Arterial Hypertension

Shuang Leng¹, Ru-San Tan^1,2, Ping Chai^3,4, Wen Ruan¹, Ting Ting Low^3,4, Lynette Teo^4,5, Tee Joo Yeo^3,4, Xiaodan Zhao¹, John C. Allen², Jonathan Yap¹, Soo Teik Lim^1,2, James W. Yip^3,4, Ju Le Tan^1,2, and Liang Zhong^1,2

¹National Heart Centre Singapore, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³National University Heart Centre, Singapore, Singapore, ⁴Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ⁵National University Hospital, Singapore, Singapore

Pulmonary artery (PA) stiffness in pulmonary arterial hypertension (PAH) is strongly associated with clinical progression of the disease. This study aimed to introduce a novel parameter—PA global longitudinal strain (GLS)—for PA stiffness assessment using a semi-automated feature-tracking approach with standard cine cardiovascular magnetic resonance (CMR). Reduced PA GLS was significantly associated with increased pulmonary artery pressure and pulmonary vascular resistance in PAH. In addition, PA GLS was significantly impaired in PAH patients with hemodynamically decompensated right ventricular (RV) function compared to those with compensated RV function.

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