Pulmonary artery (PA) stiffness in pulmonary arterial hypertension (PAH) is strongly associated with clinical progression of the disease. This study aimed to introduce a novel parameter—PA global longitudinal strain (GLS)—for PA stiffness assessment using a semi-automated feature-tracking approach with standard cine cardiovascular magnetic resonance (CMR). Reduced PA GLS was significantly associated with increased pulmonary artery pressure and pulmonary vascular resistance in PAH. In addition, PA GLS was significantly impaired in PAH patients with hemodynamically decompensated right ventricular (RV) function compared to those with compensated RV function.
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