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Abstract #0976

Impaired CMR-derived Pulmonary Artery Global Longitudinal Strain is Related to Decompensated Hemodynamics in Pulmonary Arterial Hypertension

Shuang Leng1, Ru-San Tan1,2, Ping Chai3,4, Wen Ruan1, Ting Ting Low3,4, Lynette Teo4,5, Tee Joo Yeo3,4, Xiaodan Zhao1, John C. Allen2, Jonathan Yap1, Soo Teik Lim1,2, James W. Yip3,4, Ju Le Tan1,2, and Liang Zhong1,2
1National Heart Centre Singapore, Singapore, Singapore, 2Duke-NUS Medical School, Singapore, Singapore, 3National University Heart Centre, Singapore, Singapore, 4Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 5National University Hospital, Singapore, Singapore

Pulmonary artery (PA) stiffness in pulmonary arterial hypertension (PAH) is strongly associated with clinical progression of the disease. This study aimed to introduce a novel parameter—PA global longitudinal strain (GLS)—for PA stiffness assessment using a semi-automated feature-tracking approach with standard cine cardiovascular magnetic resonance (CMR). Reduced PA GLS was significantly associated with increased pulmonary artery pressure and pulmonary vascular resistance in PAH. In addition, PA GLS was significantly impaired in PAH patients with hemodynamically decompensated right ventricular (RV) function compared to those with compensated RV function.

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