Abstract #1011

Preliminary MR elastography investigation on HIV+ cohort with cerebral small vessel disease

Abrar Faiyaz¹, Irteza Enan Kabir¹, Marvin M Doyley¹, Ingolf Sack², Md Nasir Uddin³, and Giovanni Schifitto³

¹Department of ECE, University of Rochester, Rochester, NY, United States, ²Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Department of Neurology, University of Rochester, Rochester, NY, United States

Neuroinflammation plays a crucial role in HIV-infected subjects at risk of cerebral small vessel disease. As MR-Elastography (MRE) has shown the potential to link inflammation with brain stiffness reduction, we investigated the brain viscoelastic properties of the HIV-infected and HIV-uninfected individuals. The preliminary results with MRE are promising, complementing other imaging modalities such as diffusion MRI (DTI, NODDI) to investigate brain microstructure integrity in HIV infection.

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