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Abstract #1071

Separate NAAG and NAA quantification after pediatric mild traumatic brain injury in the acute phase.

Anna Ivantsova1, Petr Menshchikov1,2,3, Andrei Manzhurtsev1,3, Maxim Ublinskii1,3, Alexey Yakovlev1,3,4, Ilya Melnikov1, Dmitrii Kupriyanov2, Tolib Akhadov1, and Natalia Semenova1,3,4
1Clinical and Research Institute of Emergency Paediatric Surgery and Traumatology, Moscow, Russian Federation, 2Clinical Science, LLC Philips Healthcare, Moscow, Russian Federation, 3Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russian Federation, 4Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation

The main finding of the study is that the tNAA signal reduction in WM after mTBI is associated with a decrease in the NAAG concentration rather than a decrease in the NAA concentration, as was thought previously. This finding highlights the importance of separating these signals, at least for WM studies, to avoid misinterpretation of the results. NAAG plays an important role in selectively activating mGluR3 receptors, thus providing neuroprotective and neuroreparative functions immediately after mTBI. NAAG shows potential for the development of new therapeutic strategies for patients with injuries of varying severity

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