Abstract #1089

Dependency of R2(*) Relaxation on Gd-DTPA Concentration in Arterial Blood: Influence of Hematocrit and Magnetic Field Strength

Daniëlle van Dorth¹, Krishnapriya Venugopal², Dirk H. J. Poot², Marion Smits², Jeroen H. J. M. de Bresser³, Juan A. Hernandez-Tamames², and Matthias J. P. van Osch¹

¹C. J. Gorter Center for High-Field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands

In quantitative dynamic susceptibility contrast (DSC) MRI measurement of the arterial input function (AIF) is required. Generally, a linear relation between the R₂^(*) relaxation and the arterial contrast agent concentration is assumed (or the AIF is measured outside of an artery), although this is invalid for gradient-echo. In this study an open-source simulation tool is adapted to determine how R₂^(*) depends on contrast concentration for different physiological and MR parameters and this tool is validated by previously acquired in vitro data. The results show that sequence type (gradient-echo versus spin-echo), hematocrit and field strength all affect the relation.

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