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Abstract #1089

Dependency of R2(*) Relaxation on Gd-DTPA Concentration in Arterial Blood: Influence of Hematocrit and Magnetic Field Strength

Daniƫlle van Dorth1, Krishnapriya Venugopal2, Dirk H. J. Poot2, Marion Smits2, Jeroen H. J. M. de Bresser3, Juan A. Hernandez-Tamames2, and Matthias J. P. van Osch1
1C. J. Gorter Center for High-Field MRI, Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, Netherlands, 3Radiology, Leiden University Medical Center, Leiden, Netherlands

In quantitative dynamic susceptibility contrast (DSC) MRI measurement of the arterial input function (AIF) is required. Generally, a linear relation between the R2(*) relaxation and the arterial contrast agent concentration is assumed (or the AIF is measured outside of an artery), although this is invalid for gradient-echo. In this study an open-source simulation tool is adapted to determine how R2(*) depends on contrast concentration for different physiological and MR parameters and this tool is validated by previously acquired in vitro data. The results show that sequence type (gradient-echo versus spin-echo), hematocrit and field strength all affect the relation.

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