Repeatability of contrast kinetic parameters of whole tumor with isotropic resolution measured by 3D-UTE-GRASP method

The repeatability of dynamic contrast enhanced (DCE)-MRI has not been fully studied, particularly with contrast kinetic parameters including intracellular water lifetime (τ_i). The purposes of this study were: (1) to investigate the repeatability of DCE-MRI with the newly proposed technique, 3D-UTE-GRASP (Golden angle Radial Sparse Parallel), which can provide isotropic high-resolution images for quantitative pharmacokinetic model analysis; and (2) to investigate the repeatability of intracellular water lifetime estimation using the two-flip angle DCE-MRI approach.