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Abstract #1097

Repeatability of contrast kinetic parameters of whole tumor with isotropic resolution measured by 3D-UTE-GRASP method

Jin Zhang1, Ayesha Bharadwaj Das1, James Tranos2, Karl Kiser1, Youssef Zaim Wadghiri2, and Gene Kim1,2
1Weill Cornell Medicine, New York, NY, United States, 2NYU Langone Health, New York, NY, United States

The repeatability of dynamic contrast enhanced (DCE)-MRI has not been fully studied, particularly with contrast kinetic parameters including intracellular water lifetime (τi). The purposes of this study were: (1) to investigate the repeatability of DCE-MRI with the newly proposed technique, 3D-UTE-GRASP (Golden angle Radial Sparse Parallel), which can provide isotropic high-resolution images for quantitative pharmacokinetic model analysis; and (2) to investigate the repeatability of intracellular water lifetime estimation using the two-flip angle DCE-MRI approach.

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