Abstract #1099

Tumor intracellular water residence time measured by DCE-MRI negatively correlates with the standard update value of 18F-FDG-PET

Karl Kiser¹, Jin Zhang¹, and S. Gene Kim^1,2

¹Radiology, Weil Cornell Medical College, New York, NY, United States, ²Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States

Intracellular water residence time (τ_i) is an important property of solid tumors, with implications in cellular energy turnover. Measurement of τ_i using the active contrast encoding MRI method offers insight into tumor microenvironment heterogeneity and potentially metabolic activity. Our study compares τ_i, measured using ACE-MRI, in mouse gliomas with the standardized uptake value (SUV) from 18F-FDG PET in order to investigate the feasibility of using τ_i as an imaging marker for cellular metabolic activity.

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