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Abstract #1099

Tumor intracellular water residence time measured by DCE-MRI negatively correlates with the standard update value of 18F-FDG-PET

Karl Kiser1, Jin Zhang1, and S. Gene Kim1,2
1Radiology, Weil Cornell Medical College, New York, NY, United States, 2Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States

Intracellular water residence time (τi) is an important property of solid tumors, with implications in cellular energy turnover. Measurement of τi using the active contrast encoding MRI method offers insight into tumor microenvironment heterogeneity and potentially metabolic activity. Our study compares τi, measured using ACE-MRI, in mouse gliomas with the standardized uptake value (SUV) from 18F-FDG PET in order to investigate the feasibility of using τi as an imaging marker for cellular metabolic activity.

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